Description

Fmoc-S-Acetamidomethyl-L-Cysteine is a specialized, orthogonally protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its core value lies in enabling the controlled incorporation of cysteine residues while preventing unwanted disulfide bond formation during synthesis. This compound is critically needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research tools. The product is supplied as a high-purity building block to ensure reliable and reproducible synthetic outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected cysteine derivative for the Fmoc/t-Bu strategy.
• Peptide Drug Development: For the synthesis of complex peptides containing cysteine, crucial for structure and activity.
• Disulfide Bridge Engineering: Enables the precise introduction of cysteine residues for controlled oxidative folding to form disulfide bonds in target peptides.
• Bioconjugation and Labeling: Serves as a handle for site-specific modification of peptides via thiol-reactive chemistry after deprotection.
• Research Grade Biochemicals: Used in academic and industrial R&D for studying protein-protein interactions and peptide structure-function relationships.
• Combinatorial Chemistry Libraries: A valuable building block for creating diverse peptide libraries for screening purposes.

Basic Information

Product Name	Fmoc-S-Acetamidomethyl-L-Cysteine
CAS No.	86060-81-3
Molecular Formula	C₂₃H₂₆N₂O₆S
Molecular Weight	458.53 g/mol
Synonyms	Fmoc-Cys(Acm)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(acetamidomethyl)-L-cysteine; Fmoc-L-Cysteine(S-acetamidomethyl); Fmoc-S-acetamidomethylcysteine; Nα-Fmoc-S-acetamidomethyl-L-cysteine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(acetamidomethyl)sulfanyl]propanoic acid; Fmoc-Cys(Acm)
EINECS	Contact for details

Quality Control

Our Fmoc-S-Acetamidomethyl-L-Cysteine is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the rigorous standards of the pharmaceutical and research industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -19.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.