Description

4-Chloro-6-(3-Fluoro-Phenyl)-Pyrimidine is a high-purity, functionalized pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile halogenated and fluorinated aromatic scaffold essential for constructing complex molecules with tailored properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form new carbon-carbon and carbon-heteroatom bonds.
• Library Synthesis for HTS: A valuable building block for creating diverse compound libraries used in high-throughput screening (HTS) campaigns to identify new lead compounds.

Basic Information

Product Name	4-Chloro-6-(3-Fluoro-Phenyl)-Pyrimidine
CAS No.	85979-60-8
Molecular Formula	C10H6ClFN2
Molecular Weight	208.62 g/mol
Synonyms	4-Chloro-6-(3-fluorophenyl)pyrimidine; 6-(3-Fluorophenyl)-4-chloropyrimidine; 4-Chloro-6-(m-fluorophenyl)pyrimidine; 85979-60-8; 4-Chloro-6-(3-fluorophenyl)pyrimidine; 4-Chloro-6-(3'-fluorophenyl)pyrimidine; Pyrimidine, 4-chloro-6-(3-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(3-Fluoro-Phenyl)-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.