Description

4-(4-Fluorophenyl)-2-Methylpyrimidine is a high-purity fluorinated pyrimidine derivative, a key heterocyclic building block prized for its structural versatility in advanced synthesis. Its core value lies in enabling the development of novel compounds with tailored properties for demanding research and industrial applications. This intermediate is essential for pharmaceutical R&D, agrochemical innovation, and materials science, serving chemists and process engineers in the fine chemical and life sciences sectors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorophenyl moiety for enhanced biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a sophisticated building block for creating novel ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science: Incorporated into the design of advanced organic electronic materials, such as charge-transport layers or emissive materials for OLEDs, due to its electron-deficient pyrimidine core.
• Chemical Biology & Proteomics: Utilized as a molecular scaffold for designing enzyme inhibitors, fluorescent probes, and other bioactive tool compounds.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	4-(4-Fluorophenyl)-2-Methylpyrimidine
CAS No.	85979-51-7
Molecular Formula	C11H9FN2
Molecular Weight	188.20 g/mol
Synonyms	2-Methyl-4-(4-fluorophenyl)pyrimidine; 4-(p-Fluorophenyl)-2-methylpyrimidine; 2-Methyl-4-(4'-fluorophenyl)pyrimidine; 4-(4-Fluorophenyl)-2-picoline; 85979-51-7; 4-(4-Fluorophenyl)-2-methyl-pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 4-(4-Fluorophenyl)-2-Methylpyrimidine is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with exacting standards for identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.