Description

D-Allothreonine, n-[(1,1-Dimethylethoxy)Carbonyl]- (9Ci) is a protected derivative of the non-proteinogenic amino acid D-allothreonine, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is of significant value in advanced organic synthesis and pharmaceutical research, where it serves as a crucial chiral building block. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of peptides, peptidomimetics, and other complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and other peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-allothreonine residue with orthogonal Boc protection strategy.
• Biochemical Research: Employed in studies of enzyme specificity, metabolic pathways, and as a standard in analytical method development for amino acid analysis.
• Fine Chemical Production: Serves as a building block for the synthesis of complex natural products, specialty chemicals, and advanced materials requiring specific stereochemistry.
• Protecting Group Chemistry: The Boc group allows for selective deprotection under mild acidic conditions, enabling complex multi-step synthetic sequences.

Basic Information

Product Name	D-Allothreonine, n-[(1,1-Dimethylethoxy)Carbonyl]- (9Ci)
CAS No.	85979-33-5
Molecular Formula	C9H17NO5
Molecular Weight	219.24 g/mol
Synonyms	Boc-D-allothreonine; (2R,3S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutanoic acid; N-Boc-D-allothreonine; N-(tert-Butoxycarbonyl)-D-allothreonine; D-allo-Threonine, N-Boc-; tert-Butyl (2R,3S)-3-hydroxy-1-oxo-1-[(1-oxobut-2-yl)amino]butan-2-ylcarbamate; (R*,S*)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxybutanoic acid
EINECS	Contact for details

Quality Control

Our D-Allothreonine, n-[(1,1-Dimethylethoxy)Carbonyl]- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.