Description

S-(2-Hydroxypropyl)Glutathione is a chemically modified derivative of the essential tripeptide glutathione, featuring a 2-hydroxypropyl group attached to the sulfur atom. This modification enhances its stability and alters its biochemical properties, making it a valuable tool in research and development for studying cellular redox mechanisms and oxidative stress. It is particularly relevant for scientists and manufacturers in the pharmaceutical, nutraceutical, and advanced biochemical sectors who require specialized glutathione analogs for investigative or formulation purposes.

Application

• Biochemical Research: Used as a stable, modified substrate or standard in enzymatic studies related to glutathione metabolism, detoxification pathways, and redox signaling.
• Pharmaceutical Development: Investigated as a potential prodrug or active pharmaceutical ingredient (API) intermediate in formulations targeting oxidative stress-related conditions.
• Nutraceutical & Cosmeceutical R&D: Explored for its enhanced stability in advanced dietary supplement or topical skincare formulations designed to support cellular antioxidant defenses.
• Enzyme Activity Studies: Serves as a specific substrate or inhibitor for glutathione S-transferases (GSTs) and other enzymes in mechanistic and kinetic assays.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, or NMR for the quantification and identification of glutathione derivatives in complex matrices.
• Cell Culture & In Vitro Models: Applied in cell-based assays to modulate intracellular glutathione levels and study the effects on apoptosis, proliferation, and response to toxins.

Basic Information

Product Name	S-(2-Hydroxypropyl)Glutathione
CAS No.	85933-29-5
Molecular Formula	C13H24N3O7S
Molecular Weight	366.41 g/mol
Synonyms	2-Hydroxypropyl Glutathione; S-(2-Hydroxypropyl)-L-glutathione; γ-L-Glutamyl-S-(2-hydroxypropyl)-L-cysteinylglycine; Glutathione S-(2-hydroxypropyl) ester; NSC 113929; L-Glutathione, S-(2-hydroxypropyl)-; Modified Glutathione; HP-GSH
EINECS	Contact for details

Quality Control

Our S-(2-Hydroxypropyl)Glutathione is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for assay, related substances, and other critical parameters. We can supply material suitable for research and development purposes, with documentation aligned with cGMP principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.