Description

4-Chloro-6-(chloromethyl)pyrimidine is a highly reactive dihalogenated pyrimidine derivative widely employed as a key building block in heterocyclic synthesis. Its dual electrophilic sites — the chloromethyl group and the electron-deficient C4 chlorine — enable selective nucleophilic substitution, making it indispensable for constructing complex pharmaceutical intermediates and agrochemical actives. This compound is critically valued by R&D chemists and process engineers in fine chemical manufacturing, particularly for scalable synthesis of kinase inhibitors, antiviral agents, and functionalized pyrimidine scaffolds. It is commercially supplied as a high-purity crystalline solid optimized for consistent reactivity and batch-to-batch reproducibility.

Application

• Synthesis of kinase inhibitors (e.g., EGFR, BTK inhibitors) via sequential alkylation and cross-coupling
• Key intermediate in the manufacture of antiviral drugs, including nucleoside analogues targeting RNA-dependent RNA polymerase
• Building block for agrochemical fungicides and herbicides, especially triazolopyrimidine-based active ingredients
• Preparation of fluorescent dyes and OLED emitters through introduction of extended π-conjugated side chains
• Chemical derivatization to generate pyrimidinyl ethers and thioethers for structure–activity relationship (SAR) studies
• Use in covalent protein labeling strategies leveraging its selective reaction with cysteine residues
• Intermediate in PET radiotracer synthesis (e.g., 18F-labeled analogues via isotopic exchange or precursor coupling)

Basic Information

Product Name	4-Chloro-6-(chloromethyl)pyrimidine
CAS No.	85878-84-8
Molecular Formula	C5H3Cl2N2
Molecular Weight	161.00 g/mol
Synonyms	4-Chloro-6-(chloromethyl)pyrimidine; 4,6-Dichloromethylpyrimidine; 4-Chloro-6-(chloromethyl)-1,3-diazine; NSC 129225; 6-(Chloromethyl)-4-chloropyrimidine; 4-Chloro-6-(chloromethyl)pyrimidine hydrochloride (impurity reference); Pyrimidine, 4-chloro-6-(chloromethyl)-; 4-Chloro-6-(chloromethyl)pyrimidine (EP Reference Standard)
EINECS	284-563-0

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to ACS Reagent Grade specifications for organic intermediates and meet REACH Annex XIV compliance requirements. Testing includes identity confirmation (IR, 1H NMR), assay (HPLC), residual solvent analysis (GC), and heavy metals screening (ICP-MS). For pharmaceutical applications, we support GMP-aligned documentation packages and can supply material meeting ICH Q7 guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccated storage conditions during long-term holding. Avoid contact with strong bases, fluorides, or oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC)	≥ 98.5%
Identification (IR)	Conforms to reference spectrum
Residue on Ignition	≤ 0.1%
Water (Karl Fischer)	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.