Description

(15-Methionine) Human Gastrin I CAS NO 85774-38-5 is a synthetic peptide analog of the human gastrin hormone, specifically modified at the methionine residue. This compound is critical for biochemical research and pharmaceutical development, particularly in studies related to gastrointestinal physiology and receptor binding. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in developing therapies for digestive disorders and hormone-related research.

Application

• Biochemical Research: Used as a high-purity reference standard and active agent in studies of gastrin receptor (CCK2R) binding, signaling pathways, and hormone activity.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of drugs targeting gastric acid secretion and gastrointestinal cancers.
• Diagnostic Manufacturing: Employed in the production of immunoassay kits, ELISA tests, and other in vitro diagnostic (IVD) reagents for measuring gastrin levels.
• Academic & Clinical Studies: Facilitates investigations into the role of gastrin in conditions like Zollinger-Ellison syndrome, peptic ulcers, and gastric endocrine cell function.
• Peptide Chemistry: Acts as a building block or model compound for studying peptide stability, modification (e.g., sulfoxidation of methionine), and synthesis techniques.

Basic Information

Product Name	(15-Methionine) Human Gastrin I
CAS No.	85774-38-5
Molecular Formula	C97H124N18O31S2
Molecular Weight	2126.3 g/mol
Synonyms	Gastrin I (human), Methionine-15-Gastrin I; Human Gastrin I (15-Met); pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2; HG I; Gastrin-17 I; Little Gastrin I; L-Gastrin I; [Met15]-Gastrin I (human).
EINECS	Contact for details

Quality Control

Our (15-Methionine) Human Gastrin I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and peptide content, mass spectrometry (MS) for identity confirmation, and tests for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., argon or nitrogen) and desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.