Description

(-)-Quinpirole Hydrochloride is a potent and selective dopamine D2/D3 receptor agonist, widely recognized for its critical role in neuroscience and pharmacological research. Its high purity and consistent quality make it an essential reference standard and active compound for investigating dopaminergic pathways, receptor function, and related neurological disorders. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on neuropharmacology, behavioral studies, and drug discovery.

Application

• Neuroscience Research: A key tool for studying dopamine D2 and D3 receptor signaling, neuronal excitability, and synaptic transmission in vitro and in vivo models.
• Pharmacological Profiling: Used as a reference agonist in receptor binding assays, functional cell-based assays (e.g., cAMP inhibition, calcium mobilization), and high-throughput screening (HTS) campaigns.
• Behavioral Studies: Employed in animal models to investigate the role of dopamine receptors in locomotion, reward, cognition, and potential implications for disorders like Parkinson's disease and schizophrenia.
• Drug Discovery & Development: Serves as a critical biochemical tool for validating new drug targets, screening compound libraries, and supporting the development of novel therapeutics targeting the dopaminergic system.
• Academic & Clinical Research: Supports fundamental research into the mechanisms of addiction, psychosis, and other central nervous system (CNS) conditions.
• Biochemical Reagent: Used in the preparation of calibration standards and controls for analytical method development and validation in bioanalytical laboratories.

Basic Information

Product Name	(-)-Quinpirole Hydrochloride
CAS No.	85760-74-3
Molecular Formula	C13H17ClN2O • HCl
Molecular Weight	289.20 g/mol
Synonyms	(-)-Quinpirole HCl; (4aR,8aR)-5-Propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline Hydrochloride; LY-171555 Hydrochloride; trans-(-)-Quinpirole Hydrochloride; Quinpirole Hydrochloride (enantiomer); Quinpirole HCl; Dopamine D2/D3 Receptor Agonist (selective)
EINECS	Contact for details

Quality Control

Our (-)-Quinpirole Hydrochloride is manufactured under strict quality control protocols to ensure the highest standards of purity and identity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable to guarantee batch-to-batch consistency and traceability, meeting the rigorous demands of pharmaceutical and advanced research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Optical Rotation	Specific range provided per COA
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.