Description

Angiotensin II, 1-Malyl-Leu(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, modified at the eighth position with a malyl-leucine residue. This modification is of significant interest for advanced biochemical research and pharmaceutical development, particularly in studying the renin-angiotensin system (RAS) and its role in cardiovascular regulation. It serves as a critical reference standard and research tool for scientists in pharmacology, endocrinology, and medicinal chemistry.

Application

• Biochemical Research: Used as a key reference standard and substrate in studies of the renin-angiotensin-aldosterone system (RAAS) and its physiological effects.
• Pharmaceutical R&D: Serves as a precursor or analog in the development of novel cardiovascular drugs, including angiotensin receptor blockers (ARBs) and enzyme inhibitors.
• Enzyme Activity Assays: Employed as a specific substrate for angiotensin-converting enzyme (ACE) and other proteolytic enzymes involved in peptide hormone metabolism.
• Receptor Binding Studies: Utilized in competitive binding assays to characterize Angiotensin II receptor subtypes (AT1 and AT2) and screen for potential therapeutic ligands.
• Metabolic Pathway Analysis: Aids in tracing and understanding the metabolic pathways and degradation products of angiotensin peptides.
• Quality Control Standards: Acts as a high-purity analytical standard for the quality control and validation of related peptide-based pharmaceuticals and reagents.

Basic Information

Product Name	Angiotensin II, 1-Malyl-Leu(8)-
CAS No.	85708-72-1
Molecular Formula	C52H78N14O14
Molecular Weight	1107.3 g/mol
Synonyms	1-Malyl-[Leu8]-Angiotensin II; [Leu8]-Angiotensin II, 1-Malyl derivative; Asp-Arg-Val-Tyr-Ile-His-Pro-Leu (1-Malyl-Leu8); Angiotensin II (1-8) heptapeptide, 1-Malyl-Leu8 analog; Malyl-Leu8-Ang II; CAS 85708-72-1; Ang II analog (1-Malyl-Leu8)
EINECS	Contact for details

Quality Control

Our Angiotensin II, 1-Malyl-Leu(8)- is manufactured under strict quality systems suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to ensure traceability and meet your specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.