Description

2-(Difluoromethoxy)Benzyl Bromide is a versatile and high-value organobromine building block, essential for introducing the difluoromethoxy-benzyl moiety into complex molecular architectures. Its primary commercial value lies in enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the difluoromethoxy group can significantly enhance metabolic stability and bioavailability. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group improves lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers and functionalized polymers with specific electronic or surface properties.
• Fluorine Chemistry Building Block: A valuable reagent for introducing both fluorine and bromine functionalities in a single step, facilitating rapid diversification in drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	2-(Difluoromethoxy)Benzyl Bromide
CAS No.	85684-64-6
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	α-Bromo-2-(difluoromethoxy)toluene; 1-(Bromomethyl)-2-(difluoromethoxy)benzene; (2-(Difluoromethoxy)phenyl)methyl Bromide; 2-(Difluoromethoxy)benzyl Bromide; Benzene, 1-(bromomethyl)-2-(difluoromethoxy)-; o-(Difluoromethoxy)benzyl Bromide; Bromomethyl(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects with material suitable for research, pilot plant, and cGMP manufacturing scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed in a dry and inert atmosphere to minimize moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.