Description

L-Glutamic Acid, n-(4-(2-(2-Amino-1,4-Dihydro-4-Oxopyrido(2,3-D)Pyrimi Din-6-Yl)Ethyl)Bezoyl)- is a specialized, high-purity chemical building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate for the production of novel therapeutic agents, particularly in the fields of oncology and targeted drug delivery. Pharmaceutical companies, biotechnology research firms, and advanced material scientists require this material for developing next-generation treatments and conducting critical structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted cancer therapies.
• Antifolate Drug Development: Used in research and production of next-generation antifolate compounds that inhibit key enzymatic pathways in disease states.
• Bioconjugation & Prodrug Synthesis: Serves as a linker or carrier molecule in the design of antibody-drug conjugates (ADCs) and prodrugs for enhanced therapeutic efficacy and reduced side effects.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme inhibition, receptor binding, and cellular uptake mechanisms.
• Preclinical & Clinical Trial Material: Supplied as a high-purity intermediate for the GMP-scale manufacture of compounds intended for regulatory submission and clinical studies.

Basic Information

Product Name	L-Glutamic Acid, n-(4-(2-(2-Amino-1,4-Dihydro-4-Oxopyrido(2,3-D)Pyrimi Din-6-Yl)Ethyl)Bezoyl)-
CAS No.	85597-18-8
Molecular Formula	C₂₁H₂₁N₅O₆
Molecular Weight	439.43 g/mol
Synonyms	N-[4-[2-(2-Amino-1,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]-L-glutamic acid; L-Glu-(EDA)-Pte; 6-[(2,4-Diaminopteridin-6-yl)methyl]amino-2-hydroxyhexanedioic acid derivative; Glutamic acid derivative of aminopterin analog; Pteroylglutamic acid analog; Antifolate intermediate; EDA-L-Glutamate conjugate. Contact for additional IUPAC names and research codes.
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development from research to commercial scale with materials suitable for preclinical and regulatory filing purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.