Description

L-Histidine Mono[3-(1H-Imidazol-4-Yl)Acrylate] is a specialized derivative of the essential amino acid L-Histidine, designed for advanced biochemical and pharmaceutical research. This compound is valued for its unique molecular structure, which incorporates an acrylate moiety linked to the imidazole ring, offering a reactive handle for conjugation and polymer synthesis. It serves as a critical building block for researchers and manufacturers in the fields of peptide chemistry, prodrug development, and the creation of novel biomaterials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted prodrugs and novel active pharmaceutical ingredients (APIs) leveraging histidine's biological role.
• Bioconjugation & Polymer Chemistry: The acrylate functional group enables its use as a monomer or cross-linker for creating smart polymers, hydrogels, and drug delivery systems.
• Biochemical Research: Used as a tool compound to study enzyme mechanisms, receptor-ligand interactions, and to develop histidine-tagged protein purification systems.
• Peptide Synthesis: Serves as a modified amino acid residue for introducing specific chemical functionality or stability into synthetic peptides.
• Cosmetic & Personal Care Actives: Potential application in the development of advanced skincare formulations where amino acid derivatives provide moisturizing or stabilizing benefits.

Basic Information

Product Name	L-Histidine Mono[3-(1H-Imidazol-4-Yl)Acrylate]
CAS No.	85586-47-6
Molecular Formula	C9H11N3O4
Molecular Weight	225.20 g/mol
Synonyms	L-Histidine acrylate derivative; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid 3-(1H-imidazol-4-yl)acrylate; Histidine acrylate; 3-(1H-Imidazol-4-yl)acrylic acid L-histidine salt; Mono-L-histidine 3-(1H-imidazol-4-yl)acrylate; 4-Imidazoleacrylic acid histidine salt; L-Histidine 3-(4-imidazolyl)acrylate
EINECS	Contact for details

Quality Control

Our L-Histidine Mono[3-(1H-Imidazol-4-Yl)Acrylate] is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.