Description

Boc-His(3-Bom)-Oh Monohydrate is a protected derivative of the amino acid L-histidine, specifically engineered for peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over the imidazole side chain during solid-phase or solution-phase peptide assembly. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis Intermediate: A key building block (amino acid derivative) for the controlled incorporation of histidine into custom peptide sequences.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Labeling: Serves as a precursor for creating histidine-tagged molecules or probes used in biochemical assays and diagnostics.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic & Institutional Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and protein engineering.
• GMP Manufacturing: Potential use in the cGMP production of active pharmaceutical ingredients (APIs) for clinical trial materials, subject to appropriate quality grades.

Basic Information

Product Name	Boc-His(3-Bom)-Oh Monohydrate
CAS No.	85484-13-5
Molecular Formula	C19H27N3O6 • H2O
Molecular Weight	411.44 g/mol (Monohydrate)
Synonyms	N-α-Boc-N-π-benzyloxymethyl-L-histidine Monohydrate; Boc-L-Histidine(N-π-Bom)-OH Monohydrate; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[1-[(benzyloxy)methyl]-1H-imidazol-4-yl]propanoic acid Monohydrate; Boc-His(Bom)-OH • H2O; Boc-His(3-Bzl-OMe)-OH Monohydrate; tert-Butoxycarbonyl-π-benzyloxymethyl-L-histidine Monohydrate; Fmoc-His(Bom)-OH precursor
EINECS	Contact for details

Quality Control

Our Boc-His(3-Bom)-Oh Monohydrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). A Certificate of Analysis (COA) detailing specific results for purity, water content, and residual solvents is provided with every shipment. We support compliance with relevant pharmacopeial standards and can supply materials suitable for research and GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); containers must be kept sealed in a desiccated environment to maintain stability and prevent hydration/degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	3.5% - 5.5% (Theoretical for monohydrate: ~4.4%)
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.