Description

Boc-D-Mephe-Oh CAS NO 85466-66-6 is a protected, non-natural amino acid derivative, specifically the Boc-protected form of D-4-methylphenylalanine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and side-chain functionality. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, protease inhibitors, and other bioactive molecules where structural integrity and purity are paramount.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-4-methylphenylalanine residue with orthogonal Boc protection.
• Protease Inhibitor Development: Serves as a core component in the design and production of specific enzyme inhibitors.
• Biochemical Research: Employed in academic and industrial R&D for studying protein-protein interactions and structure-activity relationships (SAR).
• Peptidomimetic Design: Integral for creating stable, bioavailable mimetics of natural peptides for therapeutic applications.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening of bioactive compounds.

Basic Information

Product Name	Boc-D-Mephe-Oh
CAS No.	85466-66-6
Molecular Formula	C₁₅H₂₁NO₄
Molecular Weight	279.33 g/mol
Synonyms	Boc-D-4-methylphenylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(p-tolyl)propanoic acid; N-(tert-Butoxycarbonyl)-D-4-methylphenylalanine; Boc-D-p-methylphenylalanine; Boc-D-MePhe-OH; N-Boc-D-4-methylphenylalanine; tert-Butyloxycarbonyl-D-4-methylphenylalanine; D-Boc-4-methylphenylalanine
EINECS	Contact for details

Quality Control

Our Boc-D-Mephe-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment ensures the material meets the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.