Description

2-[2-(1,3-Dimethyl-2,6-Dioxo-Purin-7-Yl)Ethyl]-1,1-Dimethyl-Guanidine Hydrochloride is a high-purity, specialized chemical building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key intermediate for synthesizing novel therapeutic agents, particularly those targeting adenosine receptor pathways. This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality raw materials for drug discovery and scale-up activities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel xanthine-derived drug candidates, particularly those acting as adenosine receptor antagonists.
• Biochemical Research: Used as a reference standard or tool compound in studies investigating purinergic signaling, neurological disorders, and cardiovascular research.
• Process Chemistry: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs) within GMP environments.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and early-stage development of new chemical entities.
• Academic Research: Utilized in university and institutional labs for fundamental medicinal chemistry projects and the exploration of new therapeutic mechanisms.

Basic Information

Product Name	2-[2-(1,3-Dimethyl-2,6-Dioxo-Purin-7-Yl)Ethyl]-1,1-Dimethyl-Guanidine Hydrochloride
CAS No.	85460-98-6
Molecular Formula	C₁₂H₁₉N₇O₂·HCl
Molecular Weight	329.79 g/mol (Free base)
Synonyms	1,1-Dimethyl-2-[2-(1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl]guanidine hydrochloride; 7-[2-(1,1-Dimethylguanidino)ethyl]-1,3-dimethylxanthine hydrochloride; 1,1-Dimethyl-2-[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-yl)ethyl]guanidine hydrochloride; Guanfacine impurity; Xanthine derivative intermediate; Adenosine receptor ligand intermediate
EINECS	Contact for details

Quality Control

Our 2-[2-(1,3-Dimethyl-2,6-Dioxo-Purin-7-Yl)Ethyl]-1,1-Dimethyl-Guanidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.