Description

5-Amino-4-Iodo-2-Fluorotoluene is a high-purity, multi-functional halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific halogen and amino functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in fluorinated and iodinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the fluorine and iodine atoms enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating specialized aromatic cores in electronic and display materials.
• Dye & Pigment Manufacturing: Employed in the synthesis of complex, high-performance colorants and imaging agents.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new synthetic methodologies and material properties.

Basic Information

Product Name	5-Amino-4-Iodo-2-Fluorotoluene
CAS No.	85233-15-4
Molecular Formula	C7H7FIN
Molecular Weight	251.04 g/mol
Synonyms	2-Fluoro-5-amino-4-iodotoluene; 4-Iodo-5-amino-2-fluorotoluene; 2-Fluoro-4-iodo-5-methylaniline; 5-Methyl-2-fluoro-4-iodoaniline; Toluene, 5-amino-4-iodo-2-fluoro-; 85233-15-4; 5-Amino-4-iodo-2-fluoro-1-methylbenzene
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-4-Iodo-2-Fluorotoluene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and identity confirmation. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.