Description

Noxiustoxin is a potent, highly specific peptide toxin derived from the venom of the scorpion *Centruroides noxius*. This compound is a valuable biochemical tool for advanced research in neuroscience and pharmacology, primarily due to its selective interaction with voltage-gated potassium channels. It is essential for researchers and pharmaceutical developers studying ion channel function, neurotoxicity mechanisms, and the development of novel therapeutic agents or diagnostic tools. The product is supplied as a high-purity, lyophilized powder to ensure optimal stability and performance in sensitive applications.

Application

• Neuroscience Research: As a specific blocker of Kv1.1, Kv1.2, and Kv1.3 potassium channels, it is used to study channel gating, neuronal excitability, and synaptic transmission.
• Pharmacological Profiling: Employed in high-throughput screening (HTS) assays to identify and characterize new drugs targeting potassium channels for conditions like autoimmune diseases, neurological disorders, and cardiac arrhythmias.
• Toxin-Antibody/Receptor Studies: Serves as a key antigen in the development and validation of antibodies, antivenoms, and biosensors.
• Cell Signaling Pathways: Used to investigate the role of specific potassium channel subtypes in immune cell activation (e.g., T-cells) and apoptosis.
• Biochemical Standard: Acts as a reference standard in analytical methods for quality control of related biopharmaceuticals or in forensic toxicology.
• Academic & Industrial R&D: Fundamental tool in university laboratories, biotech, and pharmaceutical companies for basic research and drug discovery pipelines.

Basic Information

Product Name	Noxiustoxin
CAS No.	85205-49-8
Molecular Formula	C194H296N56O55S7
Molecular Weight	~4478.1 g/mol
Synonyms	Centruroides noxius toxin; CnTx; Potassium channel toxin α-KTx 2.1; Noxiustoxin-2; Neurotoxin B-IV; κ-KTx 2.1; Scorpion toxin B-IV; Short scorpion toxin B-IV
EINECS	Contact for details

Quality Control

Every batch of Noxiustoxin is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity. Our quality control protocol includes comprehensive testing via HPLC for purity, mass spectrometry for identity confirmation, and functional bioassays to verify potency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the purity, endotoxin levels, and specific activity. We adhere to cGMP guidelines for research-grade biochemicals to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the lyophilized powder at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Assay (Functional Activity)	≥ 98%
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers
Water Content (Karl Fischer)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.