Description

Z-Hyp(Tbu)-Oh CAS NO 85201-91-8 is a protected amino acid derivative, specifically N-tert-Butyloxycarbonyl-trans-4-hydroxy-L-proline, widely used as a critical building block in peptide synthesis. Its primary value lies in providing a protected hydroxyproline residue, which is essential for constructing complex peptides and peptidomimetics with precise stereochemistry and functional group integrity. This high-purity intermediate is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality raw materials for drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing hydroxyproline.
• Pharmaceutical Intermediates: Serves as a crucial building block in the development of active pharmaceutical ingredients (APIs), particularly for collagenase inhibitors and other therapeutic peptides.
• Bioconjugation & Labeling: Used to introduce the hydroxyproline moiety into biomolecules for research, diagnostics, and targeted drug delivery systems.
• Peptidomimetic Design: Essential for creating stable, bioactive peptide analogs and mimetics in medicinal chemistry programs.
• Academic & Industrial R&D: A fundamental reagent for research into collagen structure, protein engineering, and novel peptide-based materials.
• Process Development & Scale-Up: Supplied in consistent quality for process optimization and commercial-scale manufacturing of peptide therapeutics.

Basic Information

Product Name	Z-Hyp(Tbu)-Oh
CAS No.	85201-91-8
Molecular Formula	C₁₇H₂₃NO₆
Molecular Weight	337.37 g/mol
Synonyms	N-Cbz-trans-4-Hydroxy-L-proline tert-butyl ester; (2S,4R)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid tert-butyl ester; Boc-Hyp(Tbu)-OH; Z-Hyp(OtBu)-OH; Nα-Carbobenzoxy-trans-4-hydroxy-L-proline tert-butyl ester; N-Cbz-4(R)-hydroxy-L-proline tert-butyl ester; Fmoc-Hyp(tBu)-OH precursor; Protected Hydroxyproline derivative
EINECS	Contact for details

Quality Control

Our Z-Hyp(Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-60° to -66° (c=1 in CHCl₃)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.