Description

Parathyroid Hormone (37-84) is a specific, biologically active fragment of the full-length parathyroid hormone (PTH). This high-purity peptide is critical for research into calcium metabolism, bone physiology, and endocrine signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers developing assays and therapeutic candidates related to parathyroid function and disorders.

Application

• Biomedical Research: Used as a key reagent in studies of PTH receptor (PTH1R) binding, activation, and downstream signaling cascades.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening for PTH analogs, antagonists, and modulators for osteoporosis and hypoparathyroidism treatments.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to detect PTH or related fragments in clinical samples.
• Cell Biology Studies: Applied in in vitro cell culture models to investigate the effects of PTH on osteoblast and osteoclast activity, renal calcium handling, and gene expression.
• Metabolic Disorder Research: A vital component in research models exploring hyperparathyroidism, chronic kidney disease-mineral and bone disorder (CKD-MBD), and other calcium homeostasis imbalances.
• Peptide Chemistry & Conjugation: Acts as a starting material or template for the synthesis of labeled derivatives (e.g., biotinylated, fluorescent) used in advanced detection and imaging techniques.

Basic Information

Product Name	Parathyroid Hormone (37-84)
CAS No.	85188-69-8
Molecular Formula	C₂₁₇H₃₄₇N₆₅O₆₃S₂
Molecular Weight	~5250.9 g/mol (monoisotopic)
Synonyms	PTH (37-84); Parathyroid Hormone Fragment 37-84; Human Parathyroid Hormone (37-84); hPTH (37-84); Parathyrin (37-84); PTH (37-84) (human); PTH (37-84) Peptide; CAS 85188-69-8
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (37-84) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is assured through comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.