Description

Proline, 5-Thioxo-, Methyl Ester (9Ci) CAS NO 85178-38-7 is a specialized proline derivative characterized by a thioxo (C=S) group at the 5-position and a methyl ester functionality. This compound serves as a valuable building block and intermediate in advanced organic synthesis, particularly for constructing complex molecules with specific stereochemistry and functional group arrays. It is primarily needed by research institutions and industrial R&D departments engaged in the development of pharmaceuticals, peptidomimetics, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting protease inhibition or requiring proline-based scaffolds.
• Peptidomimetics Research: Used to synthesize modified peptide analogs where the thioxo-proline moiety can influence backbone conformation and biological activity.
• Organocatalyst Precursor: Serves as a starting material for developing novel chiral catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Agrochemical Synthesis: An intermediate in the development of advanced, biologically active compounds for crop protection.
• Academic & Industrial R&D: A versatile reagent for methodological studies in organic chemistry and material science.

Basic Information

Product Name	Proline, 5-Thioxo-, Methyl Ester (9Ci)
CAS No.	85178-38-7
Molecular Formula	C7H11NO2S
Molecular Weight	173.23 g/mol
Synonyms	L-Proline, 5-thioxo-, methyl ester; Methyl 5-thioxoproline; 5-Thioxoproline methyl ester; 5-Thioxo-L-proline methyl ester; 2-Pyrrolidinecarboxylic acid, 5-thioxo-, methyl ester, (2S)-; Methyl (2S)-5-thioxo-2-pyrrolidinecarboxylate; 5-Thioxoproline methyl ester (9CI); Proline, 5-thioxo-, methyl ester (9CI)
EINECS	Contact for details

Quality Control

Our Proline, 5-Thioxo-, Methyl Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Standard quality control includes chromatographic purity analysis (HPLC) and spectroscopic identification. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.