Description

Pefloxacin n-Oxide is a key pharmaceutical intermediate and metabolite of the fluoroquinolone antibiotic pefloxacin. This compound is of significant interest in the research and development of antimicrobial agents and for analytical reference standards. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in drug metabolism, pharmacokinetic studies, and impurity profiling.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of advanced fluoroquinolone antibiotics.
• Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical manufacturing.
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetics (DMPK) research to understand the biotransformation of pefloxacin.
• Impurity Profiling: Serves as a known impurity standard to ensure the purity and safety of active pharmaceutical ingredients (APIs) according to ICH guidelines.
• Biochemical Research: Used in studies investigating the mechanism of action and resistance patterns of quinolone antibiotics.

Basic Information

Product Name	Pefloxacin n-Oxide
CAS No.	85145-21-7
Molecular Formula	C17H20FN3O4
Molecular Weight	349.36 g/mol
Synonyms	1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid N-Oxide; Pefloxacin N-Oxide; Pefloxacin Impurity D (N-Oxide); 1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid N-Oxide; Pefloxacine N-Oxide; Pefloxacin Related Compound D
EINECS	Contact for details

Quality Control

Our Pefloxacin n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.