Description

3,4-Difluorobenzyl Bromide is a versatile and high-purity organobromine building block essential for advanced organic synthesis. This compound matters as a key intermediate for introducing the difluorobenzyl moiety, enabling the development of novel compounds with enhanced properties. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where the difluorobenzyl group can improve biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: Acts as an effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and specialty chemicals with tailored properties.
• Derivatization Agent: Utilized to introduce a reactive benzyl bromide handle onto molecules for further functionalization or conjugation in chemical biology.

Basic Information

Product Name	3,4-Difluorobenzyl Bromide
CAS No.	85118-01-0
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-(Bromomethyl)-3,4-difluorobenzene; (3,4-Difluorophenyl)methyl Bromide; α-Bromo-3,4-difluorotoluene; 3,4-Difluoro-α-bromotoluene; 3,4-DFBB; 85118-01-0; 3,4-Difluorobenzylbromide
EINECS	Contact for details

Quality Control

Our 3,4-Difluorobenzyl Bromide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.