Description

Substance P (5-11), Arg(5)-Trp(7,9)- CAS NO 85077-79-8 is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 5 through 11. This fragment is a critical research tool for investigating the structure-activity relationships and receptor binding mechanisms of Substance P, particularly at the NK1 receptor. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptides for biochemical assays and experimental studies.

Application

• Neuroscience Research: Used as a key reagent to study the role of Substance P in pain transmission, neuroinflammation, and central nervous system signaling pathways.
• Pharmacological Studies: Serves as a reference standard and active compound in receptor binding assays and functional studies targeting the neurokinin-1 (NK1) receptor.
• Drug Discovery & Development: Acts as a lead compound or intermediate for the design and synthesis of novel peptide-based therapeutics targeting neurological disorders.
• Biochemical Assays: Employed in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other in vitro diagnostic tests to calibrate and validate analytical methods.
• Academic & Institutional Research: A fundamental tool for universities and research institutes conducting basic science on peptide hormones and neuropeptides.

Basic Information

Product Name	Substance P (5-11), Arg(5)-Trp(7,9)-
CAS No.	85077-79-8
Molecular Formula	C44H62N14O7
Molecular Weight	899.06 g/mol
Synonyms	Substance P Fragment 5-11; [Arg5, Trp7,9]-Substance P (5-11); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (modified); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (5-11 fragment); SP (5-11); Neurokinin P (5-11) fragment; Substance P (5-11) amide analog
EINECS	Contact for details

Quality Control

Our Substance P (5-11), Arg(5)-Trp(7,9)- is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.