Description

Dantrolene Sodium is a pharmaceutical-grade skeletal muscle relaxant used to treat malignant hyperthermia and muscle spasticity. Its primary value lies in its unique mechanism of action, which inhibits calcium release from the sarcoplasmic reticulum, making it a critical agent in anesthesia and neurology. This compound is essential for pharmaceutical manufacturers, research institutions, and compounding pharmacies developing injectable formulations and oral medications. Dantrolene Sodium CAS NO 85008-72-6 is supplied under strict quality control to ensure efficacy and safety in therapeutic applications.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of injectable and oral formulations for the treatment of malignant hyperthermia, a life-threatening condition triggered by certain anesthetics.
• Neurological Therapeutics: Used in medications for managing chronic muscle spasticity associated with conditions such as spinal cord injury, stroke, cerebral palsy, and multiple sclerosis.
• Hospital Emergency Kits: A key component in hospital emergency protocols and surgical suites, where it must be readily available to counteract hypermetabolic crises.
• Veterinary Medicine: Applied in veterinary practice for the prevention and treatment of malignant hyperthermia in susceptible animal breeds, particularly swine and certain dog breeds.
• Biomedical Research: Serves as a crucial pharmacological tool in research studies investigating calcium signaling, muscle physiology, and neuromuscular disorders.
• Compounding Pharmacy: Utilized by specialized pharmacies for preparing tailored dosage forms for patients with specific clinical needs not met by commercial products.

Basic Information

Product Name	Dantrolene Sodium
CAS No.	85008-72-6
Molecular Formula	C14H9N4NaO5
Molecular Weight	336.24 g/mol
Synonyms	Dantrolene Sodium Salt; 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione Sodium Salt; Dantrium; Dantamacrin; Sodium Dantrolene; F-368; Dantrolene; Azumolene Sodium (analog); EINECS 285-146-5
EINECS	285-146-5

Quality Control

Our Dantrolene Sodium is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs where applicable. Every batch undergoes comprehensive analytical testing for identity, potency, purity, and impurity profiles using validated methods such as HPLC, IR spectroscopy, and titration. A Certificate of Analysis (COA) is provided with each shipment, detailing all test results against specifications. Our quality system is designed to ensure consistent purity, reliability, and traceability for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange-yellow, fine crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 5.0%
Related Substances (HPLC)	Total impurities: NMT 2.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
pH (1% suspension)	9.0 - 10.5
Microbial Enumeration	Complies with USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.