Description

Glucagon, N(Alpha)-Citraconyl is a chemically modified derivative of the peptide hormone glucagon, where a citraconyl group is attached to the N(alpha)-amino group. This modification is a critical tool in peptide synthesis and biochemical research, primarily used as a reversible protecting group to prevent unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for developing therapeutic peptides and diagnostic agents. The compound enables precise structural control during complex multi-step synthesis.

Application

• Peptide Synthesis: Acts as a reversible protecting group for lysine residues during solid-phase and solution-phase peptide synthesis (SPPS).
• Bioconjugation & Protein Engineering: Used in the site-specific modification of proteins and peptides for creating targeted bioconjugates.
• Pharmaceutical Research: Serves as a key intermediate in the research and development of novel glucagon-based therapeutics and analogs.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the function of modified glucagon peptides.
• Diagnostic Agent Development: Utilized in the preparation of labeled peptides for immunoassays and other diagnostic applications.

Basic Information

Product Name	Glucagon, N(Alpha)-Citraconyl
CAS No.	84930-19-8
Molecular Formula	C156H231N43O51S
Molecular Weight	3486.8 g/mol
Synonyms	N(α)-Citraconyl-glucagon; Citraconyl-glucagon; Glucagon (1-29), N(α)-citraconyl-; Nα-Citraconylglucagon; Glucagon citraconyl derivative; H-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH (N(α)-Citraconyl); [Citraconyl1]-Glucagon
EINECS	Contact for details

Quality Control

Our Glucagon, N(Alpha)-Citraconyl is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and tests for related substances and residual solvents, ensuring it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.