Description

(S)-2-Hydroxy-4-[n-(p-Methoxybenzyloxycarbonyl)Amino]Butyric Acid is a chiral, non-proteinogenic amino acid derivative featuring a p-methoxybenzyloxycarbonyl (Moz) protecting group on the amine functionality. This compound is a critical high-purity building block for the synthesis of complex peptides and peptidomimetics, where precise stereochemistry and functional group protection are paramount. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block to introduce the (S)-2-hydroxy-4-aminobutyric acid (Hobu) residue.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various proteases (e.g., renin, HIV protease).
• Chemical Biology Research: Employed in the study of protein-protein interactions and the creation of labeled or modified peptide probes.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in the asymmetric synthesis of more complex natural products and drug candidates.
• GMP Manufacturing: Supplied under controlled conditions for use in the cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-2-Hydroxy-4-[n-(p-Methoxybenzyloxycarbonyl)Amino]Butyric Acid
CAS No.	84891-50-9
Molecular Formula	C13H17NO6
Molecular Weight	283.28 g/mol
Synonyms	(S)-HOBu(Moz); (S)-2-Hydroxy-4-[[(4-methoxyphenyl)methoxy]carbonyl]amino]butanoic acid; (S)-4-[(Moz)amino]-2-hydroxybutyric acid; (S)-N-[(4-Methoxybenzyl)oxycarbonyl]-homoserine; (S)-2-Hydroxy-4-(N-Moz-amino)butyric acid; (S)-HOSU(Moz); (S)-4-Amino-2-hydroxybutyric acid Moz derivative; L-Homoserine, N-[(4-methoxyphenyl)methoxy]carbonyl]-
EINECS	Contact for details

Quality Control

Our (S)-2-Hydroxy-4-[n-(p-Methoxybenzyloxycarbonyl)Amino]Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical identity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and impurity profiles are provided with every shipment. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.