Description

Cysteine(Fm)-Oh CAS NO 84888-38-0 is a protected derivative of the amino acid L-cysteine, where the thiol group is safeguarded by a fluorenylmethyloxycarbonyl (Fmoc) group. This protection is critical for preventing unwanted side reactions during complex peptide synthesis, ensuring high yields and purity of the final product. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in solid-phase peptide synthesis (SPPS).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the sequential assembly of peptides, particularly where cysteine incorporation is required.
• Pharmaceutical Research & Development: Used in the synthesis of therapeutic peptides, including hormones, antimicrobial peptides, and targeted drug candidates.
• Bioconjugation: The protected thiol, once deprotected, can be used for site-specific conjugation with maleimides or other thiol-reactive groups to create peptide-drug conjugates or labeled probes.
• Chemical Biology: Serves as a key reagent for studying protein-protein interactions and enzyme mechanisms through the introduction of cysteine residues.
• Production of Cysteine-Containing Peptides: Enables the reliable and scalable manufacturing of peptides that require cysteine for disulfide bridge formation, which is crucial for their three-dimensional structure and biological activity.

Basic Information

Product Name	Cysteine(Fm)-Oh
CAS No.	84888-38-0
Molecular Formula	C18H17NO4S
Molecular Weight	343.40 g/mol
Synonyms	Fmoc-Cys-OH; Fmoc-L-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-cysteine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-sulfanylpropanoic acid; N-Fmoc-L-cysteine; N-α-Fmoc-L-cysteine; Fmoc-Cysteine; L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Cysteine(Fm)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-30.0° to -34.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.