Description

Poly(Histidyl-Aspartyl-Seryl-Glycine) is a synthetic tetrapeptide composed of the amino acids histidine, aspartic acid, serine, and glycine. This sequence is of significant interest in biochemical research and pharmaceutical development due to its potential role in metal ion chelation and as a model for specific protein domains. It serves as a critical building block and research tool for scientists in life sciences, particularly those developing novel therapeutics, diagnostic agents, and studying enzyme mechanisms. Its defined structure provides a precise tool for investigating biological interactions and material properties.

Application

• Biochemical Research: Used as a standard, substrate, or inhibitor in enzymatic studies and protein interaction assays.
• Pharmaceutical R&D: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the development of novel peptide-based drugs.
• Diagnostic Development: Employed in the design and synthesis of diagnostic probes and imaging agents targeting specific biological pathways.
• Material Science: Investigated for creating bio-inspired materials, hydrogels, or coatings due to its specific amino acid sequence and properties.
• Cosmeceutical Research: Explored for potential applications in advanced skincare formulations targeting specific cellular functions.
• Neuroscience Studies: Utilized in research related to neuropeptides and neurological signal transduction mechanisms.

Basic Information

Product Name	Poly(Histidyl-Aspartyl-Seryl-Glycine)
CAS No.	84861-22-3
Molecular Formula	C19H28N8O10
Molecular Weight	528.48 g/mol
Synonyms	Histidyl-Aspartyl-Seryl-Glycine; H-Asp-Ser-Gly-OH (sequence variant reference); Tetrapeptide HDSG; Poly(His-Asp-Ser-Gly); HDG Peptide; CAS 84861-22-3; L-Histidyl-L-α-aspartyl-L-seryl-glycine
EINECS	Contact for details

Quality Control

Our Poly(Histidyl-Aspartyl-Seryl-Glycine) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and heavy metals where applicable. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions, ideally with desiccant. For long-term storage, consider storing at -20°C in aliquots to prevent repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (by HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.