Description

(S)-Lorazepam Acetate is the single enantiomer salt form of the well-established benzodiazepine derivative, lorazepam. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) where stereochemistry is a key determinant of pharmacological activity. It is primarily utilized by advanced pharmaceutical manufacturers and research institutions focused on developing novel neuropharmacological agents, chiral switches, and conducting detailed metabolic and pharmacokinetic studies.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of enantiomerically pure benzodiazepine-based Active Pharmaceutical Ingredients (APIs).
• Research & Development: Used in preclinical and clinical research to study the specific effects of the (S)-enantiomer, aiding in the development of drugs with improved efficacy and reduced side-effect profiles.
• Chiral Reference Standard: Serves as a high-purity analytical standard for method development and quality control in chiral chromatography and spectroscopy.
• Metabolic Studies: Employed in pharmacological and toxicological research to investigate the stereoselective metabolism and pharmacokinetics of lorazepam.
• Process Chemistry: Used in the development and optimization of asymmetric synthesis routes for complex pharmaceutical molecules.

Basic Information

Product Name	(S)-Lorazepam Acetate
CAS No.	84799-34-8
Molecular Formula	C₁₇H₁₄Cl₂N₂O₄
Molecular Weight	381.21 g/mol
Synonyms	(S)-Lorazepam acetate; (-)-Lorazepam acetate; (S)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one acetate; Lorazepam Impurity F (S-enantiomer acetate salt); UNII-7U6Q5S8B0C; (S)-Lorazepam acetic acid salt; (5S)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one acetate
EINECS	Contact for details

Quality Control

Our (S)-Lorazepam Acetate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.