Description

Fmoc-L-Glutamic Acid 1-tert-Butyl Ester is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for enabling the controlled, sequential assembly of complex peptides and proteins by providing orthogonal protection for the glutamic acid side chain. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing therapeutic peptides, bioactive probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating glutamic acid residues with a protected side chain carboxyl group.
• Pharmaceutical Intermediate: For the research and production of peptide-based drugs, including hormones, antibiotics, and targeted therapeutics.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Serves as a linker or spacer molecule in the synthesis of peptide-protein conjugates or peptide-drug conjugates (PDCs).
• Academic & Industrial Research: Fundamental reagent for studying protein structure-function relationships and enzyme mechanisms.
• Custom Peptide Service Providers: A standard inventory item for CROs and CDMOs offering bespoke peptide synthesis.

Basic Information

Product Name	Fmoc-L-Glutamic Acid 1-tert-Butyl Ester
CAS No.	84793-07-7
Molecular Formula	C24H27NO6
Molecular Weight	425.47 g/mol
Synonyms	Fmoc-Glu(OtBu)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 1-tert-butyl ester; Fmoc-L-Glu(OtBu)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 1-tert-butyl ester; N-α-Fmoc-L-glutamic acid γ-tert-butyl ester; Fmoc-Glutamic acid 5-tert-butyl ester; N-Fmoc-L-glutamic acid 1-tert-butyl ester; Fmoc-Glu(OtBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Glutamic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Specific Rotation	-14.0° to -16.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.