Description

Somatostatin 28, Nle(8)- is a synthetic analog of the endogenous neuropeptide somatostatin, featuring a norleucine substitution at position 8. This modification enhances its metabolic stability and receptor-binding profile, making it a critical tool for advanced biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers focused on endocrinology, oncology, and metabolic disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating somatostatin receptor (SSTR) signaling pathways and functions.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the development of novel peptide-based therapeutics targeting hormone-secreting tumors.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays (e.g., ELISA, RIA) for detecting somatostatin and related peptides.
• Academic Studies: Facilitates fundamental research in neuroendocrinology, studying the inhibition of growth hormone, insulin, and glucagon secretion.
• Receptor Binding Assays: Acts as a high-affinity ligand for characterizing SSTR subtypes and screening for receptor agonists or antagonists.

Basic Information

Product Name	Somatostatin 28, Nle(8)-
CAS No.	84768-29-6
Molecular Formula	C149H244N44O47S3
Molecular Weight	~3279.0 g/mol
Synonyms	Norleucine(8)-Somatostatin-28; [Nle8]-Somatostatin-28; Somatostatin-28 (Nle8); SRIF-28 (Nle8); Growth Hormone Release-Inhibiting Hormone (1-28), 8-Norleucine-; Ala-Gly-Cys-Lys-Asn-Phe-Phe-Nle-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bond)
EINECS	Contact for details

Quality Control

Our Somatostatin 28, Nle(8)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.