Description

4-Chloro-6-(4-Methyl-Piperazin-1-Yl)-Pyrimidin-5-Ylamine is a high-purity, functionalized pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a chloro and an amine group on the pyrimidine core, makes it a versatile intermediate for constructing complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the multi-step synthesis of final drug substances, requiring strict quality control.
• Bioconjugation & Probe Development: The reactive amine group allows for conjugation to biomolecules or fluorescent tags for diagnostic and research applications.

Basic Information

Product Name	4-Chloro-6-(4-Methyl-Piperazin-1-Yl)-Pyrimidin-5-Ylamine
CAS No.	84762-68-5
Molecular Formula	C9H13ClN6
Molecular Weight	240.70 g/mol
Synonyms	5-Amino-4-chloro-6-(4-methyl-1-piperazinyl)pyrimidine; 4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-5-amine; 5-Pyrimidinamine, 4-chloro-6-(4-methyl-1-piperazinyl)-; 4-Chloro-6-(4-methylpiperazinyl)-5-pyrimidinamine; 4-Chloro-6-(4-methylpiperazin-1-yl)-5-pyrimidinamine; 5-Amino-4-chloro-6-(N-methylpiperazino)pyrimidine; 4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-5-ylamine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(4-Methyl-Piperazin-1-Yl)-Pyrimidin-5-Ylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.