Description

2,4,5-Trichloro-4-Trifluoropyrimidine is a versatile halogenated pyrimidine building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer drug discovery programs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of fluorinated pyrimidines.
• Material Science Research: Serves as a precursor for specialty chemicals, liquid crystals, and functional materials requiring specific electronic properties.
• Cross-Coupling Reactions: The chlorine atoms provide excellent handles for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination for molecular diversification.
• Nucleoside & Nucleotide Chemistry: Acts as a fluorinated base analog in the synthesis of modified nucleosides for biochemical and therapeutic applications.

Basic Information

Product Name	2,4,5-Trichloro-4-Trifluoropyrimidine
CAS No.	84737-23-5
Molecular Formula	C4Cl3F3N2
Molecular Weight	231.42 g/mol
Synonyms	4-Trifluoromethyl-2,4,5-trichloropyrimidine; 2,4,5-Trichloro-4-(trifluoromethyl)pyrimidine; 2,4,5-Trichloro-α,α,α-trifluoropyrimidine; Pyrimidine, 2,4,5-trichloro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2,4,5-trichloropyrimidine; TCTFP
EINECS	Contact for details

Quality Control

Our 2,4,5-Trichloro-4-Trifluoropyrimidine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical synthesis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.