Description

Antithrombin Alfa is a highly purified, recombinant form of human antithrombin, a critical serine protease inhibitor that regulates the blood coagulation cascade. This product is essential for therapeutic applications where precise control of thrombin and factor Xa activity is required. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of treatments for hereditary antithrombin deficiency and other thrombotic disorders.

Application

• Therapeutic Agent Production: Primary active pharmaceutical ingredient (API) for treating hereditary antithrombin deficiency to prevent thromboembolic events during high-risk situations like surgery or childbirth.
• Biopharmaceutical Research: Critical reagent for studying the mechanisms of blood coagulation, thrombosis, and hemostasis in preclinical models.
• Diagnostic Development: Used as a standard or key component in the calibration and validation of diagnostic assays measuring antithrombin activity or antigen levels in plasma.
• Cell Culture & Protein Purification: Employed in specific bioprocessing applications to control protease activity and improve the yield and stability of other recombinant proteins.

Basic Information

Product Name	Antithrombin Alfa
CAS No.	84720-88-7
Molecular Formula	C22H32N6O5S2 (Note: This is a representative formula for a peptide segment; full protein structure is complex)
Molecular Weight	Approx. 58,200 Da (glycosylated form)
Synonyms	Recombinant Human Antithrombin; ATryn; Antithrombin III (Recombinant); rAT; Antithrombin (Recombinant); Therapeutic Antithrombin; SerpinC1 (Recombinant); Coagulation Inhibitor (Recombinant)
EINECS	Contact for details

Quality Control

Our Antithrombin Alfa is manufactured under strict cGMP guidelines for biopharmaceuticals. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety. Specifications align with relevant pharmacopeial standards for biological products. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), biological activity, endotoxin levels, and sterility is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Once reconstituted, the solution should be used immediately or stored at 2-8°C for short periods as validated. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled humidity conditions.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (HPLC/Activity)	Conforms to reference standard
Purity (SDS-PAGE & HPLC)	≥ 98.0%
Biological Activity	≥ 90% of stated potency
Protein Content	By UV absorbance
Endotoxins	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile
Moisture Content (Karl Fischer)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.