Description

(D-Arg1,D-Pro2,D-Trp7,9,Leu11)-Substance P CAS NO 84676-91-5 is a potent and selective synthetic peptide antagonist of the neurokinin-1 (NK1) receptor, a key target in neuropharmacology research. This compound is critical for studying the role of Substance P in pain transmission, inflammation, and various central nervous system disorders. It is an essential research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel therapeutics for migraine, emesis, depression, and other conditions mediated by the tachykinin system.

Application

• Neuroscience Research: Used as a selective NK1 receptor antagonist to investigate the physiological and pathological roles of Substance P in the central and peripheral nervous systems.
• Pain and Inflammation Studies: A key tool for preclinical research into neurogenic inflammation, nociception, and the development of novel analgesic drugs.
• Psychopharmacology: Employed in studies exploring the link between neurokinin signaling and conditions such as anxiety, depression, and stress responses.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening and lead optimization for NK1 receptor-targeted therapies.
• Academic & Institutional Research: Provides a reliable, high-purity reagent for fundamental biochemical and pharmacological studies in university and government laboratories.
• Biomarker Research: Utilized in assay development and validation for measuring Substance P activity and receptor binding in various biological matrices.

Basic Information

Product Name	(D-Arg1,D-Pro2,D-Trp7,9,Leu11)-Substance P
CAS No.	84676-91-5
Molecular Formula	C78H111N21O12
Molecular Weight	1546.9 g/mol
Synonyms	[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P; Substance P Antagonist; Spanide; Spanide I; Neurokinin-1 Receptor Antagonist; NK1 Antagonist; Tachykinin NK1 Receptor Antagonist; (Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2)
EINECS	Contact for details

Quality Control

Our (D-Arg1,D-Pro2,D-Trp7,9,Leu11)-Substance P is manufactured under strict quality management systems to ensure the highest standards of purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.