Description

Benzamide, n-((2,3-Dihydro-1-Methyl-5-(3-Thienyl)-1H-1,4-Benzodiazepin -2-Yl)Methyl)-, Monohydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant interest in medicinal chemistry. Its core value lies in its role as a key synthetic precursor for the development of novel therapeutic agents targeting the central nervous system. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing and scaling up production of benzodiazepine-derived active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in drug discovery programs for the design and synthesis of new chemical entities with potential anxiolytic, sedative, or muscle relaxant properties.
• Process Development & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes and scaling production from lab to pilot plant and commercial manufacturing.
• Analytical Reference Standard: Employed as a high-purity standard in HPLC, LC-MS, and NMR for quality control, method validation, and impurity profiling of related compounds.
• Biochemical Research: Investigated for its interaction with GABA-A receptors and other biological targets in neuropharmacology studies.
• Custom Synthesis: Starting point for the custom synthesis of specialized analogs and derivatives for client-specific research and development projects.

Basic Information

Product Name	Benzamide, n-((2,3-Dihydro-1-Methyl-5-(3-Thienyl)-1H-1,4-Benzodiazepin -2-Yl)Methyl)-, Monohydrochloride
CAS No.	84671-55-6
Molecular Formula	C22H22ClN3OS
Molecular Weight	411.95 g/mol
Synonyms	N-[(2,3-Dihydro-1-methyl-5-(thiophen-3-yl)-1H-1,4-benzodiazepin-2-yl)methyl]benzamide hydrochloride; 3-Thienyl-1,4-benzodiazepine derivative; 84671-55-6; Benzamide, N-[(2,3-dihydro-1-methyl-5-(3-thienyl)-1H-1,4-benzodiazepin-2-yl)methyl]-, monohydrochloride; Thienyl-substituted benzodiazepine intermediate; 1-Methyl-5-(3-thienyl)-1,4-benzodiazepine benzamide hydrochloride
EINECS	Contact for details

Quality Control

Our Benzamide, n-((2,3-Dihydro-1-Methyl-5-(3-Thienyl)-1H-1,4-Benzodiazepin -2-Yl)Methyl)-, Monohydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.