Description

Benzamide, n-((2,3-Dihydro-8-Methoxy-1-Methyl-5-(3-Thienyl)-1H-1,4-Benzodiazepin-2-Yl)Methyl)-4-(Trifluoromethyl)-, Monohydrochloride is a high-purity, complex organic compound belonging to the benzodiazepine class, specifically formulated as a monohydrochloride salt for enhanced stability and handling. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the creation of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs) for potential therapeutic applications.
• Medicinal Chemistry Research: Used as a key reference standard or starting material in drug discovery programs targeting central nervous system (CNS) disorders.
• Biochemical Research: Employed in pharmacological studies to investigate receptor binding affinity and structure-activity relationships (SAR) of modified benzodiazepine structures.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the production of complex, high-value organic molecules in custom synthesis projects.
• Reference Standard: Provides a high-purity compound for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	Benzamide, n-((2,3-Dihydro-8-Methoxy-1-Methyl-5-(3-Thienyl)-1H-1,4-Benzodiazepin-2-Yl)Methyl)-4-(Trifluoromethyl)-, Monohydrochloride
CAS No.	84671-54-5
Molecular Formula	C24H23F3N3O2S • HCl
Molecular Weight	514.98 g/mol
Synonyms	4-(Trifluoromethyl)-N-[[(2S)-8-methoxy-1-methyl-5-(3-thienyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methyl]benzamide hydrochloride; L-689,560 hydrochloride; (S)-N-[[8-Methoxy-1-methyl-5-(3-thienyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methyl]-4-(trifluoromethyl)benzamide monohydrochloride; L689560 hydrochloride; Benzamide, 4-(trifluoromethyl)-N-[[(2S)-8-methoxy-1-methyl-5-(3-thienyl-3-yl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methyl]-, monohydrochloride
EINECS	Contact for details

Quality Control

Our Benzamide, n-((2,3-Dihydro-8-Methoxy-1-Methyl-5-(3-Thienyl)-1H-1,4-Benzodiazepin-2-Yl)Methyl)-4-(Trifluoromethyl)-, Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, to ensure it meets exacting standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.