Description

n-Boc-L-Valinyl-L-Leucinyl n-Hydroxysuccinimide Ester CAS NO 84642-33-1 is a high-purity, protected dipeptide active ester widely used as a critical building block in peptide synthesis. This compound is specifically designed to facilitate efficient and selective amide bond formation, enabling the production of complex peptides and peptidomimetics. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable and high-quality intermediates for drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key coupling reagent for the sequential addition of amino acids, particularly in the synthesis of peptides containing valine and leucine residues.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methodologies for constructing peptide fragments and small peptides.
• Peptidomimetic Drug Development: Serves as a crucial intermediate in the design and synthesis of non-natural peptide analogs with enhanced stability and biological activity.
• Pharmaceutical Intermediate: Employed in the research and cGMP manufacturing of active pharmaceutical ingredients (APIs) for therapeutic peptides.
• Bioconjugation: Facilitates the site-specific labeling of peptides with fluorophores, biotin, or other functional molecules for diagnostic and research applications.
• Academic and Industrial R&D: A standard reagent in laboratories focused on medicinal chemistry, chemical biology, and proteomics research.

Basic Information

Product Name	n-Boc-L-Valinyl-L-Leucinyl n-Hydroxysuccinimide Ester
CAS No.	84642-33-1
Molecular Formula	C₂₂H₃₇N₃O₇
Molecular Weight	455.55 g/mol
Synonyms	Boc-Val-Leu-OSu; Boc-Val-Leu-NHS Ester; N-(tert-Butoxycarbonyl)-L-valyl-L-leucine N-hydroxysuccinimide ester; (3S,6S)-3-[(2S)-2-[(tert-Butoxycarbonyl)amino]-3-methylbutanamido]-4-methyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoic acid; tert-Butyl (2S)-1-[(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate; Boc-L-Val-L-Leu-OSu; Boc-Val-Leu-ONSu; N-Boc-L-valyl-L-leucine N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-L-Valinyl-L-Leucinyl n-Hydroxysuccinimide Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (HPLC), chiral purity, and moisture content. Our quality systems are designed to support customers operating under GLP and cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.