Description

N'-Fmoc-L-Lysine is a protected derivative of the essential amino acid L-lysine, featuring a 9-fluorenylmethoxycarbonyl (Fmoc) group on its side-chain ε-amino group. This strategic protection is critical for enabling the sequential, high-fidelity synthesis of peptides, particularly those requiring orthogonal deprotection strategies. It is an indispensable building block for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise control over molecular assembly. The compound is supplied to meet the stringent purity and consistency standards demanded by these high-value applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent in Fmoc-based SPPS protocols for the controlled incorporation of lysine residues.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methods for constructing peptide fragments and small cyclic peptides.
• Bioconjugation and Linker Chemistry: Serves as a key intermediate for attaching peptides to other molecules, surfaces, or solid supports via its selectively protected side chain.
• Pharmaceutical Intermediate: Employed in the research and development of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Research: Used to create modified peptide structures with enhanced stability, bioavailability, or biological activity.
• Combinatorial Library Synthesis: A vital component for generating diverse libraries of peptide-based compounds for drug discovery screening.
• Biomaterials Engineering: Incorporated into designed peptide sequences that self-assemble into hydrogels, scaffolds, or nanostructures for biomedical applications.

Basic Information

Product Name	N'-Fmoc-L-Lysine
CAS No.	84624-28-2
Molecular Formula	C21H24N2O4
Molecular Weight	368.43 g/mol
Synonyms	Fmoc-Lys-OH; N(6)-Fmoc-L-lysine; N-ε-Fmoc-L-lysine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid; Fmoc-Lysine; Nα-Fmoc-Nε-Boc-L-lysine (common protected form variant); N-α-Fmoc-N-ε-Boc-L-lysine; Boc-Lys(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our N'-Fmoc-L-Lysine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a corresponding Certificate of Analysis (COA). We support compliance with cGMP guidelines where required for pharmaceutical development. Certificates of Analysis (COA) detailing specific test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-10.0° to -12.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.