Description

3-Dehydrolithocholylglycine is a modified bile acid derivative with significant relevance in biochemical research and pharmaceutical development. This compound serves as a critical intermediate and reference standard for studying bile acid metabolism, receptor interactions, and related metabolic pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on hepatology, gastroenterology, and metabolic disease research.

Application

• Biochemical Research: Used as a key intermediate or reference standard in studies of bile acid synthesis, transport, and signaling pathways.
• Pharmaceutical Development: Serves as a building block or metabolite analog in the discovery and development of therapeutics targeting Farnesoid X Receptor (FXR) and other nuclear receptors.
• Diagnostic Reagent Manufacturing: Employed in the production of calibration standards and reagents for clinical assays measuring bile acid profiles.
• Metabolomics & Biomarker Discovery: Acts as a characterized metabolite for mass spectrometry-based studies investigating liver function and metabolic disorders.
• Enzymology Studies: Utilized as a substrate or inhibitor to study the activity of enzymes involved in bile acid conjugation and modification.

Basic Information

Product Name	3-Dehydrolithocholylglycine
CAS No.	84573-10-4
Molecular Formula	C₂₆H₄₁NO₅
Molecular Weight	447.61 g/mol
Synonyms	3-Dehydroglycolithocholic acid; N-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylglycine; Glycine, N-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]-; 3-Oxolithocholylglycine; 3-Ketolithocholylglycine
EINECS	Contact for details

Quality Control

Our 3-Dehydrolithocholylglycine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.