Description

H-Tyr-Pro-Otbu is a protected dipeptide derivative, specifically the tert-butyl ester of the tyrosine-proline dipeptide. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), offering strategic protection for the C-terminal carboxylic acid group. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers for the development of novel peptide-based therapeutics and bioactive compounds.

Application

• Pharmaceutical Intermediates: Key raw material in the synthesis of complex peptide drugs and active pharmaceutical ingredients (APIs).
• Peptide Research: Essential building block for academic and industrial research into new peptide sequences with therapeutic potential.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for drug delivery systems and diagnostic agents.
• Combinatorial Chemistry: A valuable scaffold in libraries for high-throughput screening to discover new bioactive molecules.
• Biochemical Tools: Synthesis of substrates or inhibitors for enzymatic studies and proteomics research.
• Cosmeceutical Peptides: Potential intermediate in the production of anti-aging or skin-repair peptide sequences.

Basic Information

Product Name	H-Tyr-Pro-Otbu
CAS No.	84552-63-6
Molecular Formula	C₁₈H₂₆N₂O₅
Molecular Weight	350.41 g/mol
Synonyms	H-Tyr-Pro-OtBu; L-Tyrosyl-L-proline tert-butyl ester; N-(tert-Butoxycarbonyl)-L-tyrosyl-L-proline; Boc-Tyr-Pro-OtBu; Tyrosine-Proline tert-Butyl Ester; 84552-63-6; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanamido)pyrrolidine-1-carboxylate; N-Boc-L-Tyrosyl-L-proline tert-butyl ester
EINECS	Contact for details

Quality Control

Our H-Tyr-Pro-Otbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and GMP-grade synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Specific Rotation	-40° to -50° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.