Description

Piroximone is a selective phosphodiesterase III (PDE III) inhibitor, a high-purity pharmaceutical intermediate and reference standard of significant importance in cardiovascular research and development. Its primary value lies in its potent inotropic and vasodilatory properties, making it a critical compound for studying heart failure therapeutics. This product is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on developing and testing new cardiac drugs. We supply Piroximone CAS NO 84490-12-0 to the global market with a commitment to consistent quality and reliable supply chain integrity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced cardiovascular drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical manufacturing.
• Biochemical Research: A vital tool for in vitro and in vivo studies targeting phosphodiesterase III enzyme activity and its role in cardiac muscle contraction.
• Preclinical Development: Employed in pharmacological studies to investigate positive inotropic effects and hemodynamic responses.
• Academic Research: Utilized in university and institutional labs for fundamental research on cyclic nucleotide signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Piroximone
CAS No.	84490-12-0
Molecular Formula	C₁₂H₁₁N₃O₂
Molecular Weight	229.24 g/mol
Synonyms	Piroximone; 4-Ethyl-1,3-dihydro-5-(4-pyridinylcarbonyl)-2H-imidazol-2-one; MDL 19,205; 5-(Pyridine-4-carbonyl)-4-ethyl-2,3-dihydro-1H-imidazol-2-one; 4-Ethyl-5-(4-pyridinylcarbonyl)-2,3-dihydro-1H-imidazol-2-one; 5-(4-Pyridinylcarbonyl)-4-ethyl-2,3-dihydro-1H-imidazol-2-one; MDL-19205; MDL19205
EINECS	Contact for details

Quality Control

Our Piroximone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support our global clientele's regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.