Description

2-Chloro-4-Fluoro-5-Nitrophenol is a halogenated nitrophenol derivative serving as a versatile and critical building block in advanced organic synthesis. This compound matters for its unique molecular structure, which combines electron-withdrawing groups to create a reactive scaffold for constructing complex molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing halogenated aromatic systems.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and pesticides, where the nitrophenol core is a common bioactive motif.
• Dye and Pigment Manufacturing: Serves as an intermediate for producing specialized azo dyes and colorants due to its reactive phenolic and nitro groups.
• Material Science Research: Employed in academic and industrial R&D for creating novel polymers, ligands, or functional materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Nitrophenol
CAS No.	84478-75-1
Molecular Formula	C6H3ClFNO3
Molecular Weight	191.54 g/mol
Synonyms	5-Nitro-2-chloro-4-fluorophenol; Phenol, 2-chloro-4-fluoro-5-nitro-; 2-Chloro-4-fluoro-5-nitro-1-hydroxybenzene; 4-Fluoro-2-chloro-5-nitrophenol; 84478-75-1; 2-Chloro-4-fluor-5-nitrophenol
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-Nitrophenol is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets precise customer specifications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.