Description

4-Chloro-2-Fluoro-5-(Prop-2-Yn-1-Yloxy)Aniline (Wx191843) is a specialized aniline derivative featuring chloro, fluoro, and propargyl ether substituents, making it a valuable fluorinated aromatic amine intermediate. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Used in the development of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic amine and alkyne functional groups.
• Chemical Biology Probes: The alkyne handle allows for click chemistry applications, such as CuAAC, enabling the creation of fluorescent tags or affinity probes for proteomics and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API (Active Pharmaceutical Ingredient) development.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-(Prop-2-Yn-1-Yloxy)Aniline (Wx191843)
CAS No.	84478-65-9
Molecular Formula	C9H7ClFNO
Molecular Weight	199.61 g/mol
Synonyms	5-(2-Propynyloxy)-2-fluoro-4-chloroaniline; 4-Chloro-2-fluoro-5-(2-propyn-1-yloxy)benzenamine; 2-Fluoro-4-chloro-5-(prop-2-yn-1-yloxy)aniline; 4-Chloro-2-fluoro-5-(prop-2-ynyloxy)aniline; WX-191843; Wx191843; Benzenamine, 4-chloro-2-fluoro-5-(2-propyn-1-yloxy)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-(Prop-2-Yn-1-Yloxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.