Description

Arg-Arg-Gastrin Fragment 22-30 is a synthetic peptide fragment corresponding to the C-terminal sequence of the gastrin hormone. This compound is a critical research tool for studying gastrin receptor binding, signal transduction pathways, and the physiological roles of gastrin in gastric acid secretion and mucosal growth. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers in the fields of endocrinology, gastroenterology, and oncology research.

Application

• Biochemical Research: Used as a reference standard and active ligand in receptor binding assays and signal transduction studies related to the cholecystokinin B/gastrin receptor (CCKBR).
• Pharmaceutical Development: Serves as a key intermediate or pharmacological tool in the discovery and development of gastrin receptor agonists or antagonists for therapeutic applications.
• Diagnostic Reagent Manufacturing: Employed in the production of immunoassays and ELISA kits for the detection and quantification of gastrin or related antibodies.
• Cell Biology Studies: Applied in in vitro cell culture experiments to stimulate cellular responses and investigate the role of gastrin in cell proliferation and differentiation.
• Academic & Clinical Research: Fundamental for exploring the pathophysiology of conditions like Zollinger-Ellison syndrome, peptic ulcers, and certain gastrointestinal cancers.

Basic Information

Product Name	Arg-Arg-Gastrin Fragment 22-30
CAS No.	84424-84-0
Molecular Formula	C48H78N20O12
Molecular Weight	1079.3 g/mol
Synonyms	Gastrin Fragment 22-30; H-Arg-Arg-Leu-Gly-Pro-Gln-Gly-Pro-Pro-OH; Cholecystokinin (CCK) Flanking Peptide (22-30); CCKFP (22-30); Gastrin C-terminal Nonapeptide; pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (Fragment 22-30); Gastrin I (Fragment 22-30)
EINECS	Contact for details

Quality Control

Our Arg-Arg-Gastrin Fragment 22-30 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Within ± 10% of theoretical
Peptide Content (AAA)	≥ 80.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.