Description

7-(3-Aminopyrrolidin-1-Yl)-6-Fluoro-1-(2-Fluoroethyl)-4-Oxo-1,8-Naphth Yridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance due to its role as a key building block in the synthesis of novel antibacterial agents, particularly fluoroquinolone-class antibiotics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antimicrobial therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of advanced fluoroquinolone antibiotics, contributing to the core quinolone structure essential for antibacterial activity.
• Antibacterial Drug Development: Used in R&D for creating new antibacterial agents targeting resistant bacterial strains, leveraging its fluorine and naphthyridine motifs.
• Organic Synthesis Building Block: Serves as a versatile scaffold in medicinal chemistry for constructing complex molecules with potential biological activity.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of topoisomerase inhibitors.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory compliance in API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Product Name	7-(3-Aminopyrrolidin-1-Yl)-6-Fluoro-1-(2-Fluoroethyl)-4-Oxo-1,8-Naphth Yridine-3-Carboxylic Acid
CAS No.	84424-24-8
Molecular Formula	C16H16F2N4O3
Molecular Weight	350.32 g/mol
Synonyms	1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-; 7-(3-Aminopyrrolidin-1-yl)-6-fluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 6-Fluoro-1-(2-fluoroethyl)-7-(3-aminopyrrolidin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid; ABT-492 Intermediate; ZABT-492; Z-ABT-492; Gepotidacin Intermediate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 7-(3-Aminopyrrolidin-1-Yl)-6-Fluoro-1-(2-Fluoroethyl)-4-Oxo-1,8-Naphth Yridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.