Description

5-Pyrimidinecarboxamide, 4-Ethoxy-n-((1-Ethyl-2-Pyrrolidinyl)Methyl)-2-Methyl-, Fumarate (2:5), (R)-(+)- is a high-purity, single-enantiomer pharmaceutical intermediate of significant commercial and research interest. Its value lies in its role as a key chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and neurological disorder treatments. This compound is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers requiring a reliable, high-quality source for advanced drug development and scale-up projects.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel therapeutic agents, particularly for CNS-targeting drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for creating new APIs with specific stereochemical requirements.
• Neurological Disorder Research: Serves as a key scaffold in medicinal chemistry programs focused on conditions like Parkinson's disease, schizophrenia, and other neurological targets.
• Process Chemistry & Scale-Up: Provides a consistent starting material for optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Utilized in reactions where the introduction of a specific (R)-(+)- configuration is crucial for biological activity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-Pyrimidinecarboxamide, 4-Ethoxy-n-((1-Ethyl-2-Pyrrolidinyl)Methyl)-2-Methyl-, Fumarate (2:5), (R)-(+)-
CAS No.	84413-97-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-(+)-4-Ethoxy-2-methyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-pyrimidinecarboxamide fumarate (2:5); (R)-Roxindole fumarate; Roxindole (R-enantiomer) fumarate; (R)-(+)-Roxindole fumarate; EMQ 101 (R-enantiomer); 4-Ethoxy-2-methyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-pyrimidinecarboxamide (R)-(+)-enantiomer fumarate salt
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxamide, 4-Ethoxy-n-((1-Ethyl-2-Pyrrolidinyl)Methyl)-2-Methyl-, Fumarate (2:5), (R)-(+)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical development. Each lot undergoes rigorous analytical testing, including chiral purity verification, assay, and impurity profiling. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-(+)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.