Description

Bretazenil is a high-purity benzodiazepine derivative, identified by CAS NO 84379-13-5, known for its partial agonist activity at the GABA-A receptor. This compound is of significant interest in advanced pharmaceutical research and development due to its unique pharmacological profile. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical R&D Intermediate: A key building block in the synthesis and development of novel anxiolytic and neurological therapeutic agents.
• Reference Standard: Used for analytical method development, validation, and quality control in laboratory and manufacturing settings.
• Biochemical Research: Employed in preclinical studies to investigate GABA receptor subtypes, mechanisms of action, and structure-activity relationships (SAR).
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structure for developing new chemical entities with potential therapeutic applications.
• Academic Research: Utilized in university and institutional laboratories for pharmacological and neurochemical studies.

Basic Information

Product Name	Bretazenil
CAS No.	84379-13-5
Molecular Formula	C16H14BrN3O2
Molecular Weight	360.21 g/mol
Synonyms	Ro 16-6028; 8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid ethyl ester; Ethyl 8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate; Ro-16-6028
EINECS	Contact for details

Quality Control

Our Bretazenil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.