Description

Dynorphin B (1-29) is a bioactive peptide fragment derived from the prodynorphin precursor, specifically the 29-amino acid sequence of the dynorphin B opioid peptide. This compound is a critical research tool for investigating the κ-opioid receptor (KOR) system, which is involved in pain modulation, stress response, and neuropsychiatric conditions. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical suppliers focused on neuropharmacology and peptide chemistry. The product is supplied to the highest standards to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: As a selective endogenous ligand for studying κ-opioid receptor (KOR) signaling pathways, neuronal excitability, and synaptic transmission.
• Pain Research: Investigation of endogenous pain control mechanisms, analgesic tolerance, and the development of novel non-addictive pain therapeutics.
• Psychiatric Disorder Models: Research into the role of the dynorphin/KOR system in stress, depression, anxiety, and addiction behaviors.
• Biochemical Assay Development: Use as a reference standard or competing ligand in receptor binding assays, radioimmunoassays (RIA), and ELISA kits.
• Peptide Chemistry & Pharmacology: Serving as a starting material or reference compound for structure-activity relationship (SAR) studies and the synthesis of peptide analogs.
• Cell Signaling Studies: Probing G-protein coupled receptor (GPCR) activation, internalization, and downstream second messenger systems (e.g., cAMP inhibition).

Basic Information

Product Name	Dynorphin B (1-29)
CAS No.	84376-30-7
Molecular Formula	C₁₅₀H₂₄₆N₄₂O₄₅
Molecular Weight	3359.8 g/mol
Synonyms	Dynorphin B (1-13); Dynorphin-29; Leumorphin; Rimorphin; Dynorphin B-29; Dynorphin B 1-29 amide; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-Glu-Asp-Pro-Asn-Ala-Tyr-Tyr-Glu-Glu-Leu-Phe-Asp-Val
EINECS	Contact for details

Quality Control

Our Dynorphin B (1-29) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We ensure the product meets the stringent requirements for research-grade peptides. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.