Description

5-Pyrimidinecarboxamide, n-((1-Ethyl-2-Pyrrolidinyl)Methyl)-4-Methoxy- 2-Methyl-, (R)-(+)- is a high-purity, chiral pharmaceutical intermediate of significant importance in modern drug development. Its value lies in its specific stereochemistry and functional groups, which make it a critical building block for synthesizing targeted active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries focused on developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of advanced pharmaceutical compounds, particularly for central nervous system (CNS) and neurological applications.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial precursor in multi-step synthetic routes for complex, therapeutically relevant molecules.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct molecules with defined three-dimensional configurations, essential for drug efficacy and safety.
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Fine Chemical Production: Integrated into the manufacture of specialty chemicals requiring high stereochemical purity.

Basic Information

Product Name	5-Pyrimidinecarboxamide, n-((1-Ethyl-2-Pyrrolidinyl)Methyl)-4-Methoxy- 2-Methyl-, (R)-(+)-
CAS No.	84332-41-2
Molecular Formula	C15H24N4O2
Molecular Weight	292.38 g/mol
Synonyms	(R)-(+)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-4-methoxy-2-methyl-5-pyrimidinecarboxamide; (R)-N-((1-Ethylpyrrolidin-2-yl)methyl)-4-methoxy-2-methylpyrimidine-5-carboxamide; (R)-Raclopride intermediate; (R)-OPC-14597 impurity; (R)-Enantiomer of OPC-14597; (R)-4-Methoxy-2-methyl-5-pyrimidinecarboxylic acid (1-ethyl-2-pyrrolidinylmethyl)amide; (R)-Raclopride related compound A
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediate is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.